NOX5: Molecular biology and pathophysiology

TRP Channels in Skin Biology and Pathophysiology

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or divalent cations into cells in response to a host of chemical or physical stimuli. In the skin, TRP channels are expressed in many cell types, including keratinocytes, sensory neurons, melanocytes, and immune/inflammatory cells. Within these diverse cell types, TRP channels participate in physi...

Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.

Prostate secretory protein of 94 amino acids (PSP94), primarily found in the prostatic secretion, was originally isolated and purified from human seminal plasma. PSP94 has several putative biological functions and is considered a marker of prostate cancer (PCa). Here, we review the structural-functional relationships of PSP94, address its fungicidal activity and role as an inhibitor of sperm mo...

Ascending aortic dilatation associated with bicuspid aortic valve: pathophysiology, molecular biology, and clinical implications.

Ascending aortic dilatation occurs more frequently and at a younger age in patients with bicuspid aortic valves (BAV) than it does in patients with normal trileaflet aortic valves (TAV). The clinical significance of the correlation between BAV and dilatation of the ascending aorta is based on 2 factors. First, BAV is the most common congenital cardiac abnormality, occurring in 0.46% to 1.37% of...

The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.

Molecular Pathophysiology of Stroke

Cerebral ischemia occurs when the amount of oxygen and other nutrients supplied by blood flow is insufficient to meet the metabolic demands of brain tissue. In ischemic stroke, the blood supply to the brain is disrupted by cerebrovascular disease. For decades, extensive research and clinical approaches to combat stroke have focused on the vascular aspects of cerebral ischemia. Therapeutic advan...